Degradable cross-linked polymer vesicles for the efficient delivery of platinum drugs

Abstract

Nontoxic and acid-degradable cross-linked polymeric vesicles as efficient nanocarriers for the delivery of platinum drugs are reported. Well-defined linear-brush diblock copolymers were synthesized via a robust ring opening metathesis polymerization technique and self-assembled in a selective solvent to form polymeric vesicles with bilayer structure. Vesicles were subsequently cross-linked using acid-degradable diamino ketal cross-linkers and the anticancer drug cis-platin was conjugated to the vesicles with a high loading content (17.6%) through the formation of stable chelate ring structure. This acid-degradable linker leads to a faster drug release in saline under acidic conditions (pH = ..